Elucidating the precise pharmacological mechanism of action (MOA) of naturally occurring compounds is often challenging. Though Tarselli et al. (sixty) created the primary de novo synthetic pathway to conolidine and showcased that this naturally occurring compound properly suppresses responses to both of those chemically induced and inflammation-de… Read More


Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Unlike opioids, which bind to µ-opioid receptors in the central anxious system, conolidine modulates alternate molecular targets. A Science Innovations study discovered that conolidine interacts Together with the atypical chemokine receptor ACKR3/CXCR7, which… Read More


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